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This causes acute liver injury, elevated liver enzymes, jaundice, and potential acute liver failure if severe
References Ristaino JB, Anderson PK, Bebber DP, Brauman KA, Cunniffe NJ, Fedoroff NV, Finegold C, Garrett KA, Gilligan CA, Jones CM, Martin MD, MacDonald GK, Neenan P, Records A, Schmale DG, Tateosian L, Wei Q
FDA approval is expected in 2027-2028 if Phase 3 trials are successful
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This aspect is, indeed still mysterious even if a protein with CAT feature has been described in the nuclear extract from HEK293 cells (Madiraju et al., 2009)
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